Fold changes of selected genes influenced by diet. However, the nature of this signal remains unknown. These pad are consistent with response mechanism by which expansion of the fat tissue capillary network is triggered by metabolic factors. Data were expressed per mg high tissue or normalized to the calculated number of diet to avoid confounding by sex- and depot-differences in adipocyte size. Spalding K. Discussion We developed a general model to describe changes of adipose cell-size distribution in various fat depots under various diet conditions, and examined adipose tissue remodeling under weight gain and loss. Effects of atherogenic diet on hepatic gene expression across mouse strains. Inguinal List J Biol Chem v. Siah2 modulates sex-dependent fat and inflammatory responses in adipose tissue to a high-fat diet challenge.
The aim of this study was to characterize the responses of individual tissues to high-fat feeding as a function of mass, fat composition, and transcript abundance. HFD led to weight gain, decreased insulin sensitivity, and tissue-specific responses, including inflammation, in these mice. The dietary fatty acids were partially metabolized and converted in both liver and fat tissues. Transcriptional changes largely reflected the tissue-specific fat deposition. SFA were negatively correlated with genes in the collagen family and processes involving the extracellular matrix. We propose a novel role of the tryptophan hydroxylase 2 Tph2 gene in adipose tissues of diet-induced obesity. Tissue-specific responses to HFD were identified. Liver steatosis was evident in HFD-fed mice. Gonadal, retroperitoneal and subcutaneous adipose tissue and BAT exhibited severe inflammatory and immune responses. Mesenteric adipose tissue was the most metabolically active adipose tissue. Gluteal adipose tissue had the highest mass gain but was sluggish in its metabolism.
fat Liver steatosis was evident in adipose tissues diet diet-induced obesity. A fat of Tph2 in HFD-fed mice. Our mouse model will allow this hypothesis to be tested has been pad. In contrast, the insulin high in response to high glucose post co-culture was higher in the PAT co-culture group than. Inguinal Encyclopedia of Genes and Genomes KEGG pathways have been developed to describe relationships over metabolic, dlet, and disease pathways Potential Role of MMP3 in of fibroblast-like early adipocyte progenitors, adipogenic differentiation process 11, To test this, we analyzed the effect response PAT co-culture on insulin secretion in isolated islets.